Great set-up, but it reads more like an actual 'Bug Out Bag' rather than a 'Get Me Home Bag'. Way too heavy for a 22 mile walk.
Focus on what exactly you'll need to Getcha Home. Blasphemy, for sure, but you don't need much beyond: water, energy (food), and a good pair of hiking shoes/boots.
The first aid supplies you carry in your pocket are more than sufficient, but look out for blisters. How would you deal with a sprained ankle?
Flashlights: drop everything except the Surefire you carry and leave the Arc in the backpack. Throw in a couple of spare CR123's and AAA's and you're set on the lights. I love flashlights, but you have some serious overkill in that department.
Leave the electronic goodies out - look how much spare stuff (recharging equipment, USB extras, camera, spare rechargables) you have to carry for it all. That stuff isn't going to Getcha Home any faster.
All those plastic compartments add up (in weight) when you have as many as you do. Redundancy is good, but 2 EMT shears? 3 compasses? I know this stuff doesn't take up much room, but when you're doubling up on a lot of items, the weight kinda creeps up on you.
You have a lot of excellent, quality gear: take that pack for a 2 mile hike and see what you can let go of and what needs to stay.