Spray polyurethane foam insulation (by the can) can sure help seal a house up. All you need is one little hole to access the deadspace behind the cabinet and you can fill the whole void.
Plan your use wisely. Once you start the can use it all as it will not keep. Also make sure to use low expansion foam around doors and windows. The regular stuff can actually move the jambs and block door/window operation. Yes, this was an expensive lesson in the past.
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I do the things that I must, and really regret, are unfortunately necessary.
RIP OBG