The on-line backup services may not appeal to the security paranoid crowd, but I go over it.
Online backup services do not appeal to me only because these companies come and go all the time. Yes there are some better reputed companies such as Barracuda and Mozy but in general bigger web companies have failed and I sleep better knowing that my personal or company information is not saved on one of these failed companies servers. This is regardless of HIPPA or PCI-DSS compliance...