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I'm going to have to check out that book that you referenced. The problem I have is not so much blisters but bruising toenails. Maybe that book will offer me some hope. Taping and using foam have proved useless (or worse).
I also had the same problem, especially on downhill hikes. Backpacker magazine had a short article a few years ago on some lacing methods for specific situations. I don't think you can access the entire article but here's one part.
http://www.backpacker.com/april_2003_gear_boot_lacing_tips/gear/5245This is one of the techniques that I've tried and it really helps a lot for downhill hiking.
http://www.hitthetrail.com/boot_lacing.phpThis allows you to independently adjust the tension on different parts of the shoe, so you don't have to have it too loose or too tight. On downhill hikes, you can lace the foot area tighter to prevent my feet from sliding forward, but leave the ankle part looser to prevent cutting off circulation at the ankle. Or you could modify that technique and move the knot, if you like to have more wiggle room at your toes, but tighter around the arch, and loose around the ankle. Even the direction the laces go through the eyelets (bottom up, or top down) makes a difference.
I tend to have a lot of issues with boot fitting becaues my feet are really wide and flat. Fitting boots is an entire system, socks and boots are just one part of the equation. With the right lacing technique, good socks, and also good insoles, a lot of problems can be fixed. Also, do you use hiking poles? I think trekking poles have had the most significant impact in my hiking, more than everything else combined.
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I've climbed all three "saints" (Mt San Antonio, San Gorgonio Mtn, & San Jacinto Pk), but I've never climbed San Jacinto via the C2C ("Catus to Clouds") route. Supposedly, it's one of the hardest day hikes in the United States. 10,000+ feet of gain in a day over about 17 miles (one way). It's on my list, but I'd probably just do the "Skyline" section (Palm Springs to Long Valley) which is 8000+ feet of gain over 11 miles and then ride the aerial tramway back down. The whole Catus to Clouds sounds like a bit much.
I'm definitely not in shape to do the C2C just yet, I'm thinking maybe next year. There's only a narrow window of time when the weather is agreeable, it's usually either 100 degrees at the base of the trail, or snowed out on the top of the peak.