I always do the two sock thing. Seems to work for me. I'm using Ultimax brand liner socks which are a bit thicker than dress socks. I haven't used Smartwool, but I've talked to a lot of people who have used Smartwool and really like it.
I actually carry at least two changes of socks (four pair in other words) of
varying weights. Mainly, I carry the extra socks in case I get wet (always have a pair of dry socks in case you have to bivvy), but if I start getting a hot spot, I can try a different sock. Sometimes that's all it takes.
Oh, and duct tape works really well on hot spots.
![smile smile](/images/graemlins/default/smile.gif)
Note, however, that duct tape does not breathe which can be an issue on multi day trips.