I was going to say Smith & Wesson 629 in .44 Magnum smile

But, Every one is wittering on about caliber, but has it occurred to anyone that at OS distances the big issue is going to be over penetration. You are not going to have the time to worry about who/what is behind the goblin.

So I strongly suggest that you stoke it with MagSafe's or Glazers.

One shot stop, uniformly fatal anywhere in the torso and no possibility of over penetration.
_________________________
I don't do dumb & helpless.