Why not? each piece of the lens should focus the light individually on the same focal point - there's nothing magic about it.
You just need to remember that the focal point is generally in the centre of the lens. If you break a chunk off the corner, it will still focus the light to that point - so for example, if you cut the lens into 4 pieces and use one of the pieces, then it will focus the light at the corner which was in the centre of the original lens, not in the centre of the "new" lens
I did this accidentally when my Fresnel credit-card broke and a small piece, about an inch across separated from the main piece. It did focus the light, but not nearly powerful enough to start a fire or anything.
A large Fresnel lens may not have the same optical quality as a smaller one (i.e. the focal point may be larger) in which case the cut piece may or may not be as good as a lens the same size. But it should be easy to check - just mask the large lens with a sheet of paper and see what happens.
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"The mind is not a vessel to be filled but a fire to be kindled."
-Plutarch