I would not recommend a 22. I use the most powerful handgun load I can manage. This is not a job to do feebly. You want to be thorough and deliberate about it.

The toughest so far was a horse. You'd be surprised how emotionally compelling a very pregnant young woman can be. Not something I care to repeat. Thank God I was only assisting the Vet that time. Brutal memories, but we did the best job she could've asked for.
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The ultimate result of shielding men from the effects of folly is to fill the world with fools.
-- Herbert Spencer, English Philosopher (1820-1903)