I believe it was on the Mythbusters that they debunked the idea that running the AC vs not doesn't save any gas. They did it with the trucks running against each other, one used the AC, the other not and the difference wasn't much. Basically in a year you'd never notice the difference except for being uncomfortable. If you have a 85HP engine, that might not be the case, but for most cars it is.
They revisited that one. It wasn't A/C vs not it was A/C vs windows down.
They determined in the end that it all depends on how fast you're going as the first and second episode tests had opposite results.