The Tom Bihn bags are ok IMHO - doesn't suit me. A buddy has the brain bag, not a fan of it (personal preference). Though, I own 3 brain cells (laptop sleeves) and a bunch of their accessories (i.e. freudian slip, snake charmer, etc). Give them all max kudo's for excellent quality and useablity (bags and everything else).
I personally pair up his accessories to timbuk2 bags. For my use, can't beat it.
In fact, i'm in the market for a new bag as work just gave me a workstation replacement laptop (10lbs sucker). I'm leaning towards the timbuk2 commute bags (already have one - medium), but looking at the large herringbone:
http://www.timbuk2.com/tb2/products/laptop/herringbone-commute