I was surprised to read once that a significant percentage--more than half in that particular survey--of unintentional overdoses were from combination drugs of Vicodin and Percocet which also contain acetominophen. People in chronic pain often develop resistance to the narcotics, so they increase the dosage, not realizing or not being that concerned that they're also upping the acetominophen dosage, too. I guess we're all brainwashed with TV ads that make us think that acetominophen is so safe.
I don't know the exact number, but tens of thousands ER visits are attributed to acetominophen overdoses each year.
I have a nasty leg ulcer, and my MD warned me about this. For instance, Vicodan HP is a 10/660 tablet - that 660 is meant to prevent you from taking more than 1 at a time
What my MD said "if you need more pain killer, you can add advil - up to 3, and if that doesn't work, you are off to a pain control specialist, which I'd like you to go to anyway"
Today (knock on wood) is thge lowest pain day I've had in a LONG time - JUST the Advil is working. Feels good to NOT have a narcotic running around in my system