I wouldn't be using a .410 to hunt deer...nor would I be using the .22LR obviously. .410 is a great caliber for hunting small game. I think that a .22LR/.410 combo is the ideal 'survival' firearm.

So far as I can tell there's no such thing as a once size fits all unless somebody made a .22LR/12ga over/under combo. I have found some rifles and shotguns from H & R which I'd be curious to check out.

http://www.hr1871.com/Firearms/Combos/barrel3.aspx

The Handi Rifle/Pardner 12 Ga. Combo #2 fires 12ga, 30-06, and .22LR with interchangeable barrels.