I suspect it runs on the butane only cans...but I did some Googling and it appears to come with several adapters so you never know.

As long as propane is regulated appropriately, the size of the tank doesn't matter. When I was a kid my dad got frustrated with running out during the summer on the BBQ so he hooked it up to a 200lb. tank about 5 feet tall...ran for years before needing a fill!

The problem you might have with the heaters is that many of them are designed to take the small bottle internally so adapting it might not work. The Coleman heaters for example use the bottle as part of the base so you'd have a hard time with those. I've never tried converting my propane stuff to run 20lb bottles...I love the small bottles too much.