Reddog,
Congratulations on the permit. As a rule you will want two handguns one refered to as a backup gun or BUG, I recoment that you get this one first. There is nothing wrong with a .380 an they are concidered the minimum for self defense. As for a .22 being better check out
http://www.theboxotruth.com/docs/bot26.htmwhich tests .22LR, .32ACP, .380ACP, 9x18(Makarov), and .38 special against a box filled with gallon jugs of water. A bullet will go through about twice the depth in water than it will in ballistic gelatin. The only rounds to get the recomended 12" of penetration (FBI protocol) were the .380, and the .38 special.
The reason I recomend getting a BUG first is people tend to get a small gun that they will acually carry. They also tend to get the most bang for their buck if you will as they get .380's or snubbie .38 specials.
I used to have a Seecamp .32 when that was all they made. It was almost reliable. It would shoot the first magazine empty without jams if it was cleaned and lubed at least weekly. I sold and never regretted getting rid of it. I currently have a Kel-Tec P3AT which works great. A friend has one of the new 9mms from Kel-Tec which is a little bigger than the .380. I like the .380 as it's small enough to carry in my front pants pocket and not be noticed by me or anyone else. The 9mm is just a little too big for my taste, however if I was going to only get one I would concider it.
I've carried snub nosed revolvers for years and they can't be beat, except they are wide and unless you get the light weight versions which kick like a mule, heavy enough to be an irritant. I had a steel S&W bodyguard (649) that with +P loads was the most abusive handgun I have ever fired, it was also one of the most accurate.
When some gun shop cowboy tells you you need to get "X" gun or caliber, ask them to see theirs. Don't give them time to go the the car and get it, and don't let them make excuses. If it's too much gun for them to carry, you most likely won't carry it either. You can look for a full sized pistol later once the pressure is off, and make a better decision.
A mouse gun in the hand beats a howitzer in the night stand every time.
Take Care and Stay Safe.