Good advice.

But last I checked 1500 connections worked out to once a day, every day, for over four years. In a high use model four times a day for a year.

A few things come to mind. First, multiple backups of important materials is always a good idea and this is your ultimate safety net. Second, if it is a frequently used drive with relatively valuable materials on it you might consider simply replacing it on a set schedule so it is renewed before it gives up. Don't forget to wipe, destroy or lock up the old thumb drive if your making copies you don't need. You don't want you private information to get into the wrong hands. Lastly that expected life of 1500 connections is likely based on average conditions.

Taking better than average care of the way these connections are mechanically and electrically made could considerably increase the expected life. Selecting a thumb drive that includes a good cap that will exclude dust and wear would be a good start. Of course high quality name-brand drives are likely to be a bit better made and have better plating on the contacts. Also most any electrical connections wear less if the contacts are well cleaned, lubricated with a contact conditioner and the gold plating protected with a preservative.

Caig makes a widely respected selection of contact cleaners and conditioners. I have had good luck using these products. On everything from battery contacts and circuit board connectors. The difference is often quite remarkable.