Depends on what you mean by 'long-term'.

The navy has experience with all-male and mostly-male crews (one or two females out of a crew of 1100) on extended deployments of six months or more.

Typical all and mostly male patterns include a sharp uptick in conflict and possible sporadic violence at about the six week mark. This resolves itself in a week or so and things rapidly return to normal.

A lot of it depends on the culture. The navy had to learn how to handle women on-board. It took time to develop protocols and regulations to deal with it. But once everyone was up to speed conflicts were not a major problem as long as the situation was monitored and managed.

In the very long-term, years, it would be a matter of how and how well organized the culture was. History shows many cases of female led cultures that were at least as well organized, effective and productive as male led ones. I don't see a major problem. People tend to adapt.