I suppose in the UK you can ignore 'S', as it is entirely in the Northern Hemisphere, but you have to get E and W right thanks to that tricky Greenwich Meridian. In the US, GPS positions will always be N and W.
Good point. But is always good practice to specify whether your location is either east or west of the Greenwich Meridian an North or South of the equator.
There have been occasions where the UK HM coast guard have recieved emergency rescue calls south of the equator and east of the Greenwich Meridian.
When a using a GPS to call in a emergency location, specifing the coordinate or geodetic system is good practice also.