I am reminded of two incidents that tested my driving duration limits.

The first was while in dry-dock in Seattle Shipyards. I was heading home after getting about 3 hours sleep in 3 days (you try sleeping while someone's working on your house 24/7). I had to go about 70 miles to get home, through Seattle rush hour traffic. I was in a different world by the time I got home.

The second was on a non-stop from Seattle to Tucson AZ at Christmas. We left Seattle early morning, and I drove as far as I could. I got to Sacramento and hit late night fog. By then I'd been driving about 16 hours and the fog was so bad I could see maybe two car lengths in front of me. I just kept at 65 mph the whole time and tried to watch for red lights. Dad was asleep in the back seat, and little brother was sitting next to me too scared to sleep. I finally got to the top of the grapevine when my ears gave out and I rousted dad so he could drive through north LA at 4:30 am. I sacked for about 3 hours, then woke up and drove the rest of the way. 32 hours from Seattle to Tucson. I don't know what I was trying to prove.
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The ultimate result of shielding men from the effects of folly is to fill the world with fools.
-- Herbert Spencer, English Philosopher (1820-1903)