I live in St. Louis, MO. It was ranked the #1 city for violent crime. With this said I have a BOB for this reason. I do not spend much time in the wilderness anymore, although I am an Eagle Scout, and military and LEO. Any recomendations would be most helpful. This is a list of my kit...

EDC:

DR PSP
AMK Survival Blanket
Gerber Breast Milk Bag 6 oz.
Micropur Tabs (4)
Non-Lubricated Condoms (2)
REI Storm Matches (8)
Small Multi Tool from Home Depot
CRKT M16 folding Knife
Photon Micro Light

BOB:

GI Issue Casualty Blanket w/ grommets in the corners
100 ft 550 cord
AMK 2-Person Survival Blanket(2)
Roll of Duct Tape
GI Issue Poli Pro Tops and Bottoms
Wool Socks
Underwear
T-Shirt
Wool Cap
Wool Glove Inserts
Leather Gloves
MRE's Broken Down (3)
Lipton Soup Mix (4)
Beef Bullion (8)
Chicken Bullion (8)
GI Collapsible Canteen w/ cup
Water Bottles 1L (4)
Micropur Tabs (20)
Roll Heavy Duty Aluminum Foil
Champ Swiss Army Knife
Magnesium Fire Starter
Mini Bic Lighter
Coghlan Fire Tinder (12)
Roll Quarters
$20.00 Bills (2)
Flash Drive w/ Important Documents
Pre-paid Credit Card
Phone Cards 200 mins.(2)
Weather Radio
Small FAK

I'm slightly confused here. The BOB looks fine, as does your EDC (though everyone after me will add stuff). But, you mention that you want a BOB due to St. Louis's crime rates. Yet, there's nothing in your EDC or BOB that addresses this aspect. No firearm (I lived in MO for 2 years, and know how easy it is to buy them there!), self-defense items (besides the CRKT), is your FAK equipped for a violent encounter, etc.

How do you intend to use the BOB? To leave the city when it gets too violent? That's how I'm interpreting your post, so correct me if I'm wrong.

Now my other suggestions: Given that MO can get a bit chilly, I'd throw in something heavier than Heatsheets and casualty blankets. Unless you plan on running south to the bootheel if you take off, where it's probably warmer than where I lived. Lots of bugs, so some DEET. A real flashlight with your BOB, extra batteries.

I'm sorry if I didn't mention my firearm capabilities. I have a Colt .45 Officer's model w/ Speer Gold Dot rounds and an extra mag in a fanny pack w/ the knife and a Surefire in the night stand. I also have a 12 gauge shotgun and a twenty shell bandolier next to the BOB and an extra 10 round mag for the Colt in the BOB. Also I have a mini mag w/ extra batteries in the BOB. As far as more clothing and/or other forms of warmth, the only thing I could add would be some hand/body warmers. I have the poli pro top and bottoms which could be added under clothing I would already be wearing during the fall/winter seasons. I didn't think of the bugs so thanks for the advice.

It may be a terminology thing but anytime I hear someone ask about a bug-out-bag my first Q is "Where are you bugging to?" I don't have a BOB any longer. I have a 96 hour kit and various pieces of camping gear in my truck. My Camelback is part of that gear and would be the closest thing I have to a BOB. If things got out of hand here I'd just get in the truck and drive. None of this packing stuff on my back -- that's a non-starter.

I lived in St. Louis for a while, 3/4 mile west of
the River, near the library. Not a great neighborhood:
drug dealers, pan handlers, and I am sure druggies and thieves.

More than once, I had a bus driver ask where I lived,
and he drove off his route, to where I lived,
as he explained that it was very dangerous at night.

It was my good luck, nothing ever happened. And actually I
think there are worse neighborhoods in St Louis, and
certainly in other cities.

There are a few first-hand stories I could tell, but
suffice it to say, that some of the best people I ever
met, were in St. Louis. Those good people mostly lived
in my building; they were old, poor, black, and
some were handicapped.

OTOH,Young people are always a concern. And mob can
include mature people who are dangerous.

If you do not have a concealed carry permit, get one;
you may need it if things turn bad. Some retired LEO's
get concealed carry automatically.

For bad times in a city, consider body armor, which you
already own? In addition, some thin, form fitted,
fore arm guards, analogous to soccer shin guards.
If you make them yourself, so much the better,
Kevlar mat + epoxy (or polyester) resin. They will
stop any knife and some bullets.

A clear lexan clip board of sufficient thickness to protect
from 357 40cal or 9mm. You could move it, in front of your face,
and still see where the perp was aiming. And you could aim and
fire your pistol.

I would prefer defense/offense capability that is concealed;
too many perps are agile, fast, and smart enough to get around
the obvious.

These are theoretical ideas from a non-LEO, who has not
been in a fight in many years.

+1 on the question of "where are you bugging to?" It sounds like a car kit, and you are using to get home?

For your EDC, swap out the condoms for a second milk bag- I've only ever found two uses for them, the intended one and to cover a rifle muzzle in lousy weather. As water carriers, I've never found them to not suck.

How are you carrying your EDC? And what are you using for BOB's body?

Swap the bullion cubes for ramen seasoning packets. Same thing, better packed. Trust me, the first time you realize that everything in your pack smells like bullion you'll understand this.

Small bills. Smaller than 20s. Folding money is small and light, you're better off with 5s and 1s.

I didn't see a poncho. Saw the socks, thumbs up. Everyone forgets their feet until they really need them.

Without knowing more about what your intensions are for this pack, it is really hard to say.

EDIT:
Oh- since you are in the St Louis area, check out Zombie Squad, they are based in your area. Don't let the squirrelly bits at the forum scare you off, the physical organization seems pretty solid.

I might recommend a more robust fixed blade in the BOB, like a Mora or maybe even a KA-BAR or Cold Steel SRK. I would look at swapping out the mini mag for a hand crank LED flashlight, or maybe carry both.

I have a standing recommendation for all that they should EDC dacron or similar kite/fishing string rated at 50+lbs. I EDC 25 yards of 120 lb test spooled up on a tongue depressor along with 8 yards of duct tape and 10 yards of electrical tape. It is small enough diameter it could be used as sewing thread, yet it is strong enough to lash together a shelter. It is darned good garrotte/snare material to boot.

No it is not a car kit have a seperate one. This is a BOB that would allow me to get out of Dodge and head west about 20 miles to stay with family for a while. Last summer a storm knocked out a good portion of the electricity in the city for over five days. I would not consider staying in my home should something similiar happen again. I have cheap ponchos in the car kit and two in the BOB. Sorry I keep finding more things that I've crammed in there. The body of the BOB is a REI backpack. The EDC is repackaged in an Alosak bag and carried in either, a fanny pack, coat pocket, briefcase, or cargo pocket depending on the situation. I will definitely check out the ramen packets. Thanks.

I have been looking into adding a mora to the BOB. I would also like to add a decent head lamp. As far as cordage goes, I use 550 cord for everything. I have wrapped the body of the mag light with it as well as replacing the bootlaces in the boots that I keep under the bed.

So your plan is to cover 20 miles -- why not include a cheap bike?
doubles your weight carrying at 4 times the speed of walking.