After spending a couple years living and working in the NYC area, I have to conclude that the biggest issues to think about are:

Public Transit failure (Amtrak line broke again, arrgh!!!)

Blackout (Someone fell through another broken grate and blew the Con Ed xformer again, arrgh!!!)

What the heck is that smell? and how am I going to eat while it stinks like that? For Christ's sake, I can taste the smell, Blecchhh!!!!

Are they ever going to get that POS FDR Gondola ride across East River fixed?

Where is the nearest gym so I can go work on losing all the weight I'm gaining from eating all this wonderful pizza, without getting jacked up on the way there or back?

I wonder where I can find a whole body profylactic like they used in that Naked Gun movie so I can walk through that Times Square crowd at the end of the day without fear of catching some disease?

Where do I put the pocket pistol so that it doesn't imprint and Mr. Officer doesn't catch me with it, or the Train Gestapo either for that matter?

When the building elevator where I work tanks and I get stuck for an hour again, what games should I download on my blackberry to pass the time with?

and probably the biggest one:

How can I avoid getting run over by those crazy insane bicycle couriers?