Bingley, not sure of your firearms background, but the decision is dependent on a couple of things...
auto loaders...typically have much lighter trigger pull (especially one handed) but due to the breach locking design are limited to bullet weights less than 250 grains (7000 grains per pound), and a velocity of around 1600 feet per second...
Somewhat of a generalization and there are exceptions. For example, there's the Desert Eagle in .50 AE. Love to shoot it, would hate to carry it. ;=)
In large calibers, generally a revolver is also much lighter and capacity is more closely matched to what a similar sized semi-auto would be. All my clients going to or residing in AK have carried large frame revolvers, if they carry a handgun.
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