Bingley, not sure of your firearms background, but the decision is dependent on a couple of things...

auto loaders...typically have much lighter trigger pull (especially one handed) but due to the breach locking design are limited to bullet weights less than 250 grains (7000 grains per pound), and a velocity of around 1600 feet per second... they do offer more rounds in a magazine than a revolver...a hot rodded 10mm Glock would be my choice, though a good friend carries a .460 Roland conversion when elk hunting

wheel guns (revolvers) come in two varieties, double action where the trigger pull both rotates the cylinder and raises the hammer, and single action where you must manually raise the hammer... the single action trigger is much lighter, but is best put into service by two hands... the stronger revolver action allows much higher pressures to be generated by the cartridge, but limits the number of rounds to five or six in .45 caliber models... most dangerous game cartridges use a monolithic bullet with blunt nose as they are not used in an auto loading pistol.... additionally a .454 Casull can handle a 350 or so grain bullet at velocities pushing 1900 fps, but the firearm can still shoot lower powered .45 Colt cartridges for practice... that would be my choice in a Ruger Redhawk