Comparing a .22 to a .22-250 is apples to nukes...
My point with the 22-250 was not the power, it is about bullet placement. I feel very confident of my bullet placement ability.
I know people that upon occasion take a deer down with a 22 lr by shooting it in the head (Not me as I don’t hunt deer.)
Don't underestimate a 22 because it looks small.
I work at my friends gun shop part time am around a lot of gun people.