I had one of my 1GB flash drives fry on me tonight. Luckily, nothing I need was stored on it, but it reminded me of something I haven't thought about for a while: Make sure you have multiple backups!
If you store any important information in an electronic medium, make sure you have more than one backup, preferably in multiple forms!
On a side note, after reading up on flash technology, it seems like most normal consumer drives are made to last for about 10,000 read/write cycles and 1,500 connections. Therefore, using your usb drive as little as 1500 times could be enough to kill it. That's something to keep in mind if you plan on using a USB drive for long term information storage.
Just thought I would mention it on here, in case anyone is putting off backing their data or only has it backed up on one drive.