Some are. Some aren't. Some depends on the hunter. I don't use scopes on any of my pistols and they are all comfy to shoot one-handed. If I was shooting off a ladder in a Texas beanfield, I would agree - long range pistols are what you describe for heft and balance. There are other kinds of terrain / methods of hunting.

One handed assumes an off-hand shot, which I try like the dickens to avoid with rifle or pistol. Off a rest it doesn't take two hands. Handguns can be grossly more sensitive or grossly less sensitive than a rifle to POI shift off a rest - depends on pistol, ammo, and the specific point of contact on the rest - the range is the right place to find out the particulars.

Handgun hunting is high art and not for the novice - but in the large bores it doesn't require a canon, long barrel, or optics. Stalking skill, strong ethics, and superb marksmanship are what it takes.

Just my 2 cents.