I'm not sure how the UV wand users deal with potentially contaminated water on the outside lip of the bottle - unless one is just very careful to pour the water in the bottle without getting any on the outside lip/threads - a funnel might help.
i use a one-half liter stainless steel mug that fits on the bottom of my one liter nalgene to collect the water - good to get those hard to reach water sources + has the benefit of allowing heavier debris to sink to the bottom of the mug - before carefully pouring the unclean water into the nalgene. then steripen (the aforementioned uv wand) for 90 secs and voila, you're done.
a microbiologist might argue this point, but i believe that unless the water is heavily contaminated with organisms or has very virulent organisms in it, a few drops on the rim shouldn't cause any great distress. the body needs a certain amount of colonies to cause distress.
i am NOT saying to ignore the threads. but a drop or two shouldn't hurt you.